Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years
Identifieur interne : 002203 ( Main/Exploration ); précédent : 002202; suivant : 002204Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years
Auteurs : Ivar Mendez [Canada] ; Angel Vi Uela [États-Unis] ; Arnar Astradsson [États-Unis] ; Karim Mukhida [Canada] ; Penelope Hallett [États-Unis] ; Harold Robertson [Canada] ; Travis Tierney [États-Unis] ; Renn Holness [Canada] ; Alain Dagher [Canada] ; John Q. Trojanowski [États-Unis] ; Ole Isacson [États-Unis]Source :
- Nature medicine [ 1078-8956 ] ; 2008.
English descriptors
- KwdEn :
- Brain Tissue Transplantation (methods), Brain Tissue Transplantation (pathology), Fetal Tissue Transplantation (methods), Fetal Tissue Transplantation (pathology), Humans, Immunohistochemistry, Male, Middle Aged, Neurons (pathology), Parkinson Disease (diagnostic imaging), Parkinson Disease (therapy), Positron-Emission Tomography, Treatment Outcome, Tyrosine 3-Monooxygenase.
- MESH :
- chemical : Tyrosine 3-Monooxygenase.
- diagnostic imaging : Parkinson Disease.
- methods : Brain Tissue Transplantation, Fetal Tissue Transplantation.
- pathology : Brain Tissue Transplantation, Fetal Tissue Transplantation, Neurons.
- therapy : Parkinson Disease.
- Humans, Immunohistochemistry, Male, Middle Aged, Positron-Emission Tomography, Treatment Outcome.
Abstract
Postmortem analysis of five subjects with Parkinson’s disease9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.
Url:
DOI: 10.1038/nm1752
PubMed: 18391961
PubMed Central: 2656682
Affiliations:
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Le document en format XML
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uniqKey="Tierney T" first="Travis" last="Tierney">Travis Tierney</name><affiliation wicri:level="1"><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478</wicri:regionArea><wicri:noRegion>Massachusetts 02478</wicri:noRegion></affiliation></author><author><name sortKey="Holness, Renn" sort="Holness, Renn" uniqKey="Holness R" first="Renn" last="Holness">Renn Holness</name><affiliation wicri:level="1"><nlm:aff id="A1">Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and 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Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7</wicri:regionArea><wicri:noRegion>Nova Scotia B3H 3A7</wicri:noRegion></affiliation></author><author><name sortKey="Vi Uela, Angel" sort="Vi Uela, Angel" uniqKey="Vi Uela A" first="Angel" last="Vi Uela">Angel Vi Uela</name><affiliation wicri:level="1"><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478</wicri:regionArea><wicri:noRegion>Massachusetts 02478</wicri:noRegion></affiliation></author><author><name sortKey="Astradsson, Arnar" sort="Astradsson, Arnar" uniqKey="Astradsson A" first="Arnar" last="Astradsson">Arnar Astradsson</name><affiliation wicri:level="1"><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478</wicri:regionArea><wicri:noRegion>Massachusetts 02478</wicri:noRegion></affiliation></author><author><name sortKey="Mukhida, Karim" sort="Mukhida, Karim" uniqKey="Mukhida K" first="Karim" last="Mukhida">Karim Mukhida</name><affiliation wicri:level="1"><nlm:aff id="A1">Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7</wicri:regionArea><wicri:noRegion>Nova Scotia B3H 3A7</wicri:noRegion></affiliation></author><author><name sortKey="Hallett, Penelope" sort="Hallett, Penelope" uniqKey="Hallett P" first="Penelope" last="Hallett">Penelope Hallett</name><affiliation wicri:level="1"><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478</wicri:regionArea><wicri:noRegion>Massachusetts 02478</wicri:noRegion></affiliation></author><author><name sortKey="Robertson, Harold" sort="Robertson, Harold" uniqKey="Robertson H" first="Harold" last="Robertson">Harold Robertson</name><affiliation wicri:level="1"><nlm:aff id="A1">Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7</wicri:regionArea><wicri:noRegion>Nova Scotia B3H 3A7</wicri:noRegion></affiliation></author><author><name sortKey="Tierney, Travis" sort="Tierney, Travis" uniqKey="Tierney T" first="Travis" last="Tierney">Travis Tierney</name><affiliation wicri:level="1"><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478</wicri:regionArea><wicri:noRegion>Massachusetts 02478</wicri:noRegion></affiliation></author><author><name sortKey="Holness, Renn" sort="Holness, Renn" uniqKey="Holness R" first="Renn" last="Holness">Renn Holness</name><affiliation wicri:level="1"><nlm:aff id="A1">Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Departments of Anatomy & Neurobiology and Pharmacology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7</wicri:regionArea><wicri:noRegion>Nova Scotia B3H 3A7</wicri:noRegion></affiliation></author><author><name sortKey="Dagher, Alain" sort="Dagher, Alain" uniqKey="Dagher A" first="Alain" last="Dagher">Alain Dagher</name><affiliation wicri:level="1"><nlm:aff id="A3">McGill University and Montreal Neurological Institute, McConnell Brain Imaging Centre, 3801 University Street, Montreal, Quebec H3A 2B4, Canada.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Canada</country><wicri:regionArea>McGill University and Montreal Neurological Institute, McConnell Brain Imaging Centre, 3801 University Street, Montreal, Quebec H3A 2B4</wicri:regionArea><wicri:noRegion>Quebec H3A 2B4</wicri:noRegion></affiliation></author><author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q" last="Trojanowski">John Q. Trojanowski</name><affiliation wicri:level="1"><nlm:aff id="A4">Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging of the University of Pennsylvania, NINDS Udall Parkinson’s Disease Research Center of Excellence, 3600 Spruce Street, Philadelphia, Pennsylvania 19104, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging of the University of Pennsylvania, NINDS Udall Parkinson’s Disease Research Center of Excellence, 3600 Spruce Street, Philadelphia, Pennsylvania 19104</wicri:regionArea><wicri:noRegion>Pennsylvania 19104</wicri:noRegion></affiliation></author><author><name sortKey="Isacson, Ole" sort="Isacson, Ole" uniqKey="Isacson O" first="Ole" last="Isacson">Ole Isacson</name><affiliation wicri:level="1"><nlm:aff id="A2">Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Harvard University and McLean Hospital, US National Institute of Neurological Disorders and Stroke (NINDS) Udall Parkinson’s Disease Research Center of Excellence, 115 Mill Street, Belmont, Massachusetts 02478</wicri:regionArea><wicri:noRegion>Massachusetts 02478</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature medicine</title><idno type="ISSN">1078-8956</idno><idno type="eISSN">1546-170X</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain Tissue Transplantation (methods)</term><term>Brain Tissue Transplantation (pathology)</term><term>Fetal Tissue Transplantation (methods)</term><term>Fetal Tissue Transplantation (pathology)</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Neurons (pathology)</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (therapy)</term><term>Positron-Emission Tomography</term><term>Treatment Outcome</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Brain Tissue Transplantation</term><term>Fetal Tissue Transplantation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain Tissue Transplantation</term><term>Fetal Tissue Transplantation</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Positron-Emission Tomography</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P4">Postmortem analysis of five subjects with Parkinson’s disease9–14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.</p></div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Mendez, Ivar" sort="Mendez, Ivar" uniqKey="Mendez I" first="Ivar" last="Mendez">Ivar Mendez</name></noRegion><name sortKey="Dagher, Alain" sort="Dagher, Alain" uniqKey="Dagher A" first="Alain" last="Dagher">Alain Dagher</name><name sortKey="Holness, Renn" sort="Holness, Renn" uniqKey="Holness R" first="Renn" last="Holness">Renn Holness</name><name sortKey="Mukhida, Karim" sort="Mukhida, Karim" uniqKey="Mukhida K" first="Karim" last="Mukhida">Karim Mukhida</name><name sortKey="Robertson, Harold" sort="Robertson, Harold" uniqKey="Robertson H" first="Harold" last="Robertson">Harold Robertson</name></country><country name="États-Unis"><noRegion><name sortKey="Vi Uela, Angel" sort="Vi Uela, Angel" uniqKey="Vi Uela A" first="Angel" last="Vi Uela">Angel Vi Uela</name></noRegion><name sortKey="Astradsson, Arnar" sort="Astradsson, Arnar" uniqKey="Astradsson A" first="Arnar" last="Astradsson">Arnar Astradsson</name><name sortKey="Hallett, Penelope" sort="Hallett, Penelope" uniqKey="Hallett P" first="Penelope" last="Hallett">Penelope Hallett</name><name sortKey="Isacson, Ole" sort="Isacson, Ole" uniqKey="Isacson O" first="Ole" last="Isacson">Ole Isacson</name><name sortKey="Tierney, Travis" sort="Tierney, Travis" uniqKey="Tierney T" first="Travis" last="Tierney">Travis Tierney</name><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q" last="Trojanowski">John Q. 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